蛇葡萄素和运动模拟剂在慢性疾病中的生物功能及机制 本书特色

蛇葡萄素（Ampelopsin）又名双氢杨梅素（dihydromyricetin，DMY）是藤茶中一种重要的黄酮类物质。研究表明，Ampelopsin具有广泛的生物学功能：抗炎、抗氧化、抗肿瘤、保肝、改善运动疲劳等。
本书首从Ampelopsin的结构入手，然后分章节来探讨Ampelopsin的抗炎、抗氧化、抗肿瘤、保肝、神经保护、改善运动疲劳及衰老性肌萎缩的作用；阐明Ampelopsin发挥上述作用的信号分子或者靶标；Ampelopsin发展成为功能性食品的前景。

蛇葡萄素和运动模拟剂在慢性疾病中的生物功能及机制 内容简介

蛇葡萄素（Ampelopsin）又名双氢杨梅素（dihydromyricetin，DMY）是藤茶中一种重要的黄酮类物质。研究表明，Ampelopsin具有广泛的生物学功能：抗炎、抗氧化、抗肿瘤、保肝、改善运动疲劳等。本书首从Ampelopsin的结构入手，然后分章节来探讨Ampelopsin的抗炎、抗氧化、抗肿瘤、保肝、神经保护、改善运动疲劳及衰老性肌萎缩的作用；阐明Ampelopsin发挥上述作用的信号分子或者靶标；Ampelopsin发展成为功能性食品的前景。

蛇葡萄素和运动模拟剂在慢性疾病中的生物功能及机制 目录

The Biological Function and Molecular Mechanism of Ampelopsin and Exercise Mimetics in Chronic DiseasesContentsChapter 1Pharmacological potential of ampelopsin in Rattan tea1
Chapter 2Ampelopsin reduces endotoxic inflammation via repressing ROS?mediated
activation of PI3K/Akt/NF?κB signaling pathways8
Chapter 3Natural products for cancer prevention associated with Nrf2?ARE pathway23
Chapter 4Anti?tumor effect31
4.1Potential molecular targets of ampelopsin in prevention and treatment of
cancers31
4.2Nutraceutical or pharmacological potential of Moringa oleifera Lam.39
4.3Ampelopsin induces apoptosis in HepG2 human hepatoma cell line through
extrinsic and intrinsic pathways：involvement of p38 and ERK48
Chapter 5Neuroprotective effect59
5.1Ampelopsin inhibits H2O2?induced apoptosis by ERK and Akt signaling
pathways and up?regulation of heme oxygenase?159
5.2Ampelopsin attenuates 6?OHDA?induced neurotoxicity by regulating
GSK?3β/NRF2/ARE signaling67
Chapter 6Autophagy and brain aging77
6.1Autophagy as the modulator of neuronal homeostasis and neurodegenerative disorders77
6.2Resveratrol as a natural autophagy regulator for prevention and treatment of Alzheimer’s disease80
6.3Ampelopsin attenuates brain aging of D?gal?induced rats through miR?34a?mediated SIRT1/mTOR signaling pathway89
6.4Swimming attenuates D?galactose?induced brain aging via suppressing miR?34a?mediated autophagy impairment and abnormal mitochondrial dynamics101
6.5Voluntary wheel running exercise suppresses brain aging of rats through activating miR?130a?mediated autophagy112
Chapter 7Sarcopenia123
7.1Research progress of sarcopenia123
7.2MicroRNA?regulated proinflammatory cytokines in sarcopenia127
7.3Ampelopsin attenuates D?gal?induced oxidative stress?related skeletal muscle atrophy through activating AMPK/SIRT1/PGC?1α signaling cascade135
7.4Role and regulation of autophagy in mass maintenance of skeletal muscle147
Acknowledgement155
References156

蛇葡萄素和运动模拟剂在慢性疾病中的生物功能及机制 作者简介

寇现娟，女，副教授。健康科学学院运动医学教研室教师。郑州大学医学院生物化学与分子生物学专业硕士，华中科技大学同济医学院生物化学与分子生物学专业博士。

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医学 药学 药学理论

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