6.1 Introduction 183
6.2 Magnetic nanoparticles and magnetic characteristics 185
6.2.1 Preparation， surface modification， assembly of magnetic nanoparticles 185
6.2.2 Special features of magnetic nanoparticles 186
6.2.3 Biomedical applications of magnetic nanoparticles 190
6.2.4 Ultrasonic characteristics of magnetic nanoparticles liquid 192
6.3 Microbubble formalism and acoustic characteristics 193
6.3.1 Design and preparation of microbubbles 193
6.3.2 Actions of MBs with ultrasound waves 194
6.4 Magnetic and acoustic character of magnetic microbubbles (MMBs) 197
6.4.1 Fabrication of magnetic microbubbles 197
6.4.2 Acoustic response of magnetic microbubbles 198
6.4.3 Magnetic response of magnetic microbubbles 200
6.5 Applications of magnetic microbubbles in biomedicine 203
6.5.1 Multimodal imaging of MMBs 203
6.5.2 Ultrasound assisted drug delivery of MMBs 204
6.5.3 Magnetic field-controlled drug delivery and release of MMBs 204
6.6 Summary and perspectives 205
References 205
Chapter 7 Multifunctional Magnetic Nanoparticles for Magnetic Resonance Image-guided Photothermal Therapy for Cancer 209
7.1 Introduction 210
7.2 ICG-loaded MNPs for MR/fluorescence bimodal image-guided PTT 211
7.2.1 Fabrication of ICG-loaded SPIO NPs 211
7.2.2 In vivo MR/fluorescence bimodal imaging of ICG-loaded SPIO NPs 212
7.2.3 In vivo photothermal therapy with ICG-loaded SPIO NPs 214
7.3 Gold-nanoshelled magnetic cerasomes for MRI-guided photothermal therapy 214
7.3.1 Cerasomes combine the advantages of both liposomes and silica nanoparticles 214
7.3.2 Contrast-enhanced MRI imaging using GNMCs 216
7.3.3 Synergistic e.ect in killing cancer cells using GNMCs 216
7.4 Gold-nanoshelled magnetic nanocapsules for MR/ultrasound bimodal image-guided photothermal therapy 217
7.4.1 SPIOs-embedd

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